Ua hoʻomohala nā mea noiʻi mai ke Keʻena Mechanical and Aerospace Engineering (MAE) o ke Kula ʻo ʻEnekinia ʻo Herbert Wertheim i kahi ʻano hou o ka hemodialysis membrane i hana ʻia me ka graphene oxide (GO), kahi mea i hoʻopaʻa ʻia i ka monoatomic.Manaʻo ʻia e hoʻololi loa i ka mālama ʻana i ka dialysis kidney me ka hoʻomanawanui.Hiki i kēia holomua ke hoʻopili i ka microchip dialyzer i ka ʻili o ka mea maʻi.Ke hana nei ma lalo o ke kaomi arterial, e hoʻopau ia i ke kahe koko a me ke kaapuni koko extracorporeal, e ʻae ai i ka dialysis palekana i ka ʻoluʻolu o kou home.Ke hoʻohālikelike ʻia me ka membrane polymer e kū nei, ʻo ka permeability o ka membrane he ʻelua mau kauoha o ka nui o ke kiʻekiʻe, loaʻa ka hoʻohālikelike koko, a ʻaʻole maʻalahi ka paona e like me nā membrane polymer.
Ua hoʻomohala ʻo Polofesa Knox T. Millsaps o MAE a me ka mea noiʻi alakaʻi o ka pāhana membrane ʻo Saeed Moghaddam a me kāna hui i kahi kaʻina hana hou e pili ana i ka hui ʻana iho a me ka hoʻonui ʻana i nā waiwai kino a me nā mea kemika o GO nanoplatelets.Hoʻololi wale kēia kaʻina hana i nā ʻāpana 3 GO i mau hui nanosheet i hoʻonohonoho pono ʻia, a laila e loaʻa ai ka ultra-high permeability a me ke koho."Ma ka hoʻomohala ʻana i kahi membrane i ʻoi aku ka nui o ka permeable ma mua o kāna mea olaola, ka glomerular basement membrane (GBM) o ka puʻupaʻa, ua hōʻike mākou i ka mana nui o nā nanomaterials, nanoengineering, a me ka molecular self-assembly."Ua'ōleloʻo Mogda Dr. Mu.
ʻO ke aʻo ʻana i ka hana membrane i nā hiʻohiʻona hemodialysis ua hoʻopuka i nā hopena hoʻoikaika.ʻO nā sieving coefficients o ka urea a me ka cytochrome-c he 0.5 a me 0.4, i lawa ia no ka dialysis lohi lōʻihi me ka mālama ʻana ma mua o 99% o albumin;ua hōʻike ʻia nā haʻawina e pili ana i ka hemolysis, complement activation a me ka coagulation ua hoʻohālikelike ʻia lākou me nā mea membrane dialysis i loaʻa A ʻoi aku ka maikaʻi ma mua o ka hana ʻana o nā mea membrane dialysis.Ua paʻi ʻia nā hopena o kēia noiʻi ma Advanced Materials Interfaces (Februari 5, 2021) ma lalo o ke poʻo inoa "Trilayer Interlinked Graphene Oxide Membrane for Wearable Hemodialyzer".
Ua'ōleloʻo Dr. Moghaddam: "Ua hōʻike mākou i kahi GO nanoplatelet i hoʻonohonoho ponoʻia i ka mosaic, kahi e holomua nui ai i ka hoʻoikaikaʻana i nā makahiki heʻumi i ka hoʻomohalaʻana i nā membranes graphene."He kahua kūpono ia e hiki ai ke hoʻonui i ka dialysis pō haʻahaʻa ma ka home. "Ke hana nei ʻo Kauka Moghaddam i ka hoʻomohala ʻana i nā microchips me ka hoʻohana ʻana i nā membrane GO hou, kahi e lawe mai ai i ka noiʻi kokoke i ka ʻoiaʻiʻo o ka hāʻawi ʻana i nā mea hemodialysis hiki ke hoʻohana ʻia no nā maʻi maʻi maʻi.
Ua ʻōlelo ʻo Nature's Editorial (Malaki 2020): "Ua manaʻo ka World Health Organization ma kahi o 1.2 miliona mau kānaka e make ana i ka maʻi kīkī i kēlā me kēia makahiki ma ka honua holoʻokoʻa [a ʻo ka loaʻa ʻana o ka maʻi renal hope (ESRD) ma muli o ka maʻi diabetes a me ka hypertension]….ʻO ka Dialysis ʻO ka hui pū ʻana o nā palena kūpono o ka ʻenehana a me ka hiki ke loaʻa iā ia ka liʻiliʻi o ka hapalua o ka poʻe e pono ai ka mālama ʻana.ʻO nā hāmeʻa hiki ke hoʻohana miniaturized kūpono he hopena waiwai e hoʻonui ai i nā helu ola, ʻoi aku hoʻi i ka hoʻomohala ʻana o Kina."ʻO kā mākou membrane he mea koʻikoʻi o kahi ʻōnaehana hiki ke hoʻohana ʻia, hiki ke hana hou i ka hana filtration o ka puʻupaʻa, hoʻomaikaʻi nui i ka hōʻoluʻolu a me ka uku ma ka honua holoʻokoʻa," wahi a Kauka Moghaddam.
"ʻO nā holomua nui i ka mālama ʻana i nā maʻi me ka hemodialysis a me ka hana ʻole o ka renal i kaupalena ʻia e ka ʻenehana membrane.ʻAʻole i holomua ka ʻenehana membrane i nā makahiki i hala iho nei.Pono ka holomua o ka ʻenehana membrane e hoʻomaikaʻi i ka dialysis renal.Hiki ke hoʻololi i ka paradigm kahi mea paʻa loa a koho ʻia, e like me ka membrane ultra-thin graphene oxide i kūkulu ʻia ma ʻaneʻi.ʻAʻole hiki ke ʻike wale nā ​​​​membrane permeable ultra-thin i nā miniaturized dialyzers, akā ʻo nā mea lawe lima maoli a hiki ke hoʻohana ʻia, no laila e hoʻomaikaʻi ai i ka maikaʻi o ke ola a me ka wānana maʻi.Ua ʻōlelo ʻo James L. McGrath he kumu ʻo ia no ka ʻenekinia biomedical ma ke Kulanui o Rochester a he mea hoʻokumu i kahi ʻenehana membrane ultra-thin silicon hou no nā noi olaola like ʻole (Nature, 2007).
Ua loaʻa kālā kēia noiʻi e ka National Institute of Biomedical Imaging and Bioengineering (NIBIB) ma lalo o ka National Institutes of Health.ʻO ka hui o Kauka Moghaddam e komo pū me Kauka Richard P. Rode, ka hoa postdoctoral ma UF MAE, ʻo Kauka Thomas R. Gaborski (ka mea noiʻi kumu nui), ʻo Daniel Ornt, MD (ka mea noiʻi kumu nui), a me Henry C o ke Keʻena ʻOihana Biomedical. 'enekinia, Rochester Institute of Technology .Kauka Chung a me Hayley N. Miller.
He lālā ʻo Kauka Moghaddam o ka UF Interdisciplinary Microsystems Group a ke alakaʻi nei i ka Nanostructured Energy Systems Laboratory (NESLabs), ʻo kāna misionari ka hoʻomaikaʻi ʻana i ka pae ʻike o ka nanoengineering o nā hale porous hana a me ka micro/nanoscale transmission physics.Hoʻohui ʻo ia i nā ʻano aʻoaʻo he nui o ka ʻenekinia a me ka ʻepekema e hoʻomaopopo maikaʻi i ka physics o ka micro/nano-scale transmission a hoʻomohala i nā hale a me nā ʻōnaehana o ka hanauna hou me ka hana kiʻekiʻe a me ka maikaʻi.
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